Thousands of researches in the science of birthing and living

Dr Michel Odent has collected thousands of scientific researches in prenatal life, birth, post partum and family matter in a huge Primal Health Research Databank.Paragraph. 

Epigenetic

Resilience

Prenatal maternel stress

“Children of women who experienced six or more self-reported stressful life events during pregnancy, regardless of the timing, were at about four times greater risk of developing mental health problems later in life.
In another study, high  Corticotropin-releasing hormone (CRH) levels during gestation were correlated with decreased physical and neuromuscular maturity, which has been associated with impaired brain development and motor development abnormalities.
Longitudinally, evidence points to an association between high levels of prenatal maternal cortisol and fearful and reactive behaviors of offspring (Davis et al., 2011). Babies who were exposed to high levels of stress in utero tend to be more reactive after birth, show more behavioral inhibition and anxiety during infancy, toddlerhood, and childhood, and display a slower rate of recovery from stress responses.
They are also more likely as toddlers and children to have greater physiological arousal to challenges, to display anxiety or fear in new situations, to have higher stress reactivity and poorer emotional and attentional regulation (Davis, 2011).
But an infant’s brain is still very malleable after birth. Positive patterns in early life, especially in the first year, can heal trauma and enable a baby to develop the cortisol receptors and relax into a less-stressed state, from which it will develop accordingly. Social supports, a nurturing home environment, and bonding techniques such as parent-infant massage can help mothers and their partners adjust to parenthood with less stress. This will have a direct and positive impact on babies exposed to high prenatal levels of stress hormones (McClure, 2000).”
Anna Humphreys
Extract from Prenatal Maternal Stress: Neurological and Physiological Impacts on Offspring
(Published 09/2015)

Mother attachment and quality of our relationship

This study is stunning to understand the importance of tenderness in the early childhood.
As Dr. Peter Denov said: "the love of the mother build the intelligence of the child".
Bethany Saltman "The most important parenting you’ll ever do happens before your child turns one — and may affect her for the rest of her life. One mother’s journey through the science of attachment."

“The brain undergoes the most critical development in children in the first 36 months. Since all behavior is regulated by the brain, therefore early intervention is important.”Jianghong Liu

According to a large body of research, the early risk factors that may predispose a child to violence include teen pregnancy, birth complications, lead exposure, head injury, child abuse, and maternal stress and depression. Jianghong Liu, an assistant professor at Penn’s School of Nursing and School of Medicine, argues that these factors, whether biological, psychological or environmental, can interact with each other early on, increasing the odds of a lifetime of violent behavior.
“We can do something about it,” Liu said. “It’s not that expensive, compared to the money government puts into prisons. Why not spend the money on prenatal care or on developing a parenting skill? I’m confident parents would like it.”
Current theories on violence and aggression focus on the risks for adolescents. Liu makes the case for implementing prevention programs during the prenatal period and first three years of a child’s life — and even before conception — to head off the possibility of early brain dysfunction and later aggression.

Amazing research for a new paradigm in the matter or life

Pr Bryan Kolb​
  1. Leonard, C.M. (1969). The prefrontal cortex of the rat. I. Cortical projection of the mediodorsal nucleus. II. Efferent connections. Brain Research, 12, 321-343
  2. Kolb, B. (1984). Functions of the frontal cortex of the rat: A comparative review. Brain Research Reviews, 8, 65-98
  3. Uylings, H., Groenewegen, H., & Kolb, B. (2003) Does the rat have a prefrontal cortex? Behavioural Brain Research, 146, 3-17
  4. Kolb, B. (1995). Brain plasticity and behavior. Hillsdale, NJ: Lawrence Erlbaum
  5. Kolb, B., Mychasiuk, R., Muhammad, A., & Gibb, R. (2013). Brain plasticity in the developing brain. Progress in Brain Research, 207: 35-64.
  6. Kolb, B., Gibb, R., Gorny, G. & Whishaw, I.Q. (1998) Possible brain regrowth after cortical lesions in rats. Behavioural Brain Research, 91, 127-141.
  7. Monfils, M.-H., Driscoll, I., Kamitakahara, H, Wilson, B., Flynn, C., Teskey, G.C., Kleim, J.A., & Kolb, B. (2006) FGF-2-induced cell proliferation stimulates anatomical, neurophysiological, and functional recovery from neonatal motor cortex injury. European Journal of Neuroscience, 24 ,740-749.
  8. Robinson, T.E. & Kolb, B. (2004) Structural plasticity associated with drugs of abuse. Neuropharmacology, 47 Suppl 1, 33-46.
  9. Mychasiuk, R., Muhammad, A., Carroll, C., & Kolb B. (2013) Does Prenatal Nicotine Exposure Alter the Brain’s Response to Nicotine in Adolescence? A Neuroanatomical Analysis. European J Neuroscience, 38, 2491-2503.
  10. Himmler, B.T., Pellis, S.M., & Kolb, B. (2013). Juvenile play experience primes neurons in the medial prefrontal cortex to be more responsive to later experiences. Neuroscience Letters, 556, 42-45.
  11. Mychasiuk, R., Muhammad, A., Gibb, R., & Kolb B. (2013) Long-term alterations to dendritic morphology and synaptic connectivity associated with prenatal exposure to nicotine. Brain Research, 1499, 53-60.
  12. Kolb, B., Mychasiuk, R., Muhammad, A., & Gibb, R. (2013). Brain plasticity in the developing brain. Progress in Brain Research, 207: 35-64.
  13. Milstein, J.A., Elnabawi. A., Swanson, T., Enos, J.K., Bailey, A.M., Kolb, B., & Frost, D.O. (2013). Olanzapine treatment of adolescent rats causes enduring specific memory impairments and alters cortical development and function. PLoS ONE, 8(2):e57308.
  14. Mychasiuk, R., Muhhamad, A. & Kolb, B. (2014) Environmental Enrichment Alters Structural Plasticity of the Adolescent Brain But Does Not Remediate the Effects of Prenatal Nicotine Exposure. Synapse, 68: 293-305.
  15. Mychasiuk, R., Muhammad, A., Ilnytsky, S., & Kolb, B. (2013). Persistent Gene Expression Changes in NAc, mPFC, and OFC Associated with Previous Nicotine or Amphetamine Exposure. Behavioural Brain Res, 256, 655-651.
  16. Muhammad, A., Mychasiuk, R., Hosain, R., Nakahashi, A., Carroll, C, Gibb, R., & Kolb, B. Training on motor and visual spatial learning tasks in early adulthood produces large changes in dendritic organization of prefrontal cortex and nucleus accumbens in rats given nicotine prenatally. Neurosc, 252, 178-189.
  17. Kolb, B. and Gibb, R. (2014). Searching for principles of brain plasticity and behavior. Cortex, 58C:251-260.
  18. Kolb, B. & Muhammad, A. (2014). Harnassing the power of neuroplasticity for intervention. Frontiers in Neuroscience, 8:377 doi: 10.3389.
  19. Himmler, B.T., Nakahashi, A., Snow, E., McMickle, A., Muhammad, A., Biondolillo, K.D., Pellis, S.M., & Kolb, B. (2014). Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats. Developmental Psychobiology, 56: 1052-60.
  20. Gibb, R.L., Gonzalez, C.L., and Kolb, B. (2014) Prenatal enrichment and recovery from perinatal cortical damage: effects of maternal complex housing. Frontiers in Behavioral Neuroscience 8:223, doi:103389.
​
​ Pr Mikhael Meany​
Other meaningful researches and publications
  • de Rosnay, J. 2013,
  • (Kenrick, D. 2011, Renovating the Pyramid of Needs: Contemporary Extensions Built Upon Ancient Foundations, Perspect -Psychol Sci., PMC3161123
  • Bannister, A. J., Schneider, R., and Kouzarides, T. (2002). Histone methylation: dynamic or static? Cell 109 , 801-806.
  • Carrozza, M. J., Utley, R. T., Workman, J. L., and Cote, J. (2003). The diverse functions of histone acetyltransferase complexes. Trends Genet 19 , 321-329.
  • Khan, A. U., and Hampsey, M. (2002). Connecting the DOTs: covalent histone modifications and the formation of silent chromatin. Trends Genet 18 , 387-389.
  • Lacoste, N., Côté, J. (2003). The epigenetic code of histones; 19(10):955-9
  • Turner, B. M. (2002). Cellular memory and the histone code. Cell 111 , 285-291.
  • Zhang, Y., and Reinberg, D. (2001). Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 15 , 2343-2360.
  • Atlan Pr, H (1999) The end of the all-genetic. Toward new paradigms in biology? INRA editions
  • MORSE, WILEY, Ghosts from the Nursery, The Atlantic Monthly press, NY,1997, 364 pp.
  • MOORE, PERSAUD, The Developing Human, Clinically oriented embryology, Édition Saunders, 6th edition 1998,USA, 563 pp.
  • Parenting for peace, Marcy Axness, PhD
  • Chamberlain, David: “The Mind of Your Newborn Baby”
  • Correia, Inez: “The Impact of Television Upon the Unborn Baby, A Pioneer Study”
  • Davis-Floyd, Robbie: “Birth as an American Rite of Passage”
  • FRYMANN, The Collected Papers of Viola M. Frymann, D.O. Legacy of Osteopathy to Children, American Academy of osteopathy.
  • + Stress and the Commensal Microbiota: Importance in Parturition and Infant Neurodevelopment Tamar L. 2015 PMC4313583
  • Women’s Experiences of Group Prenatal Care Gina Novick, 2012 PMC3085399
  • Prenatal Care in Combination with Maternal Educational Level Has a Synergetic Effect on the Risk of Neonatal Low Birth Weight: New Findings in a Retrospective Cohort Study in Kunshan City, China
    Lin-Lin Dai, 2014, PMC4245141
  • Women's and care providers' perspectives of quality prenatal care: a qualitative descriptive study Wendy Sword, 2012, PMC3352181
  • Childbirth Education and Obstetric Interventions Among Low-Risk Canadian Women: Is There a Connection? Kathrin H. Stoll, 2012, PMC3489119 ++ Published online 2010 Jun. doi:
    10.2478/v10102-010-0012-4
  • Dubovický, M., 2010, Neurobehavioral manifestations of developmental impairment of the brain, PMC2984125
  • Semin Fetal Neonatal Med. 2012 doi: 10.1016/j.siny.2011.10.001. Diversity of microbes in amniotic fluid. DiGiulio DB
  • Semin Perinatol. 2013 Apr;37(2):94-101. doi: 10.1053/j.semperi.2013.01.005. Ureaplasma and BPD. Kallapur SG1, Kramer BW, Jobe AH.
  • Chorioamnionitis and neonatal outcome in preterm infants: a clinical overview. Pugni L, 2015, PMID: 26135227
  • Eukaryote-Made Thermostable DNA Polymerase Enables Rapid PCR-Based Detection of Mycoplasma, Ureaplasma and Other Bacteria in the Amniotic Fluid of Preterm Labor Cases. Ueno T, 2015, PMID:
    26042418
  • Whitley GS, 2007 , Increased apoptosis in first trimester extravillous trophoblasts from pregnancies at higher risk of developing preeclampsia. PMC1899436
  • The effectiveness of a prenatal education programme for the prevention of congenital toxoplasmosis. A. O. Carter, 1989, PMC2249529
  • Factors Associated with Alcohol Use, Depression, and Their Co-occurrence during Pregnancy Doris McGartland Rubio, 2008, PMC2746640 Keywords: alcohol use, depression, co-occurrence,
    pregnancy, risk factors Conclusions Smoking, older age, lower education, and illicit substance use predicted alcohol and/or probable depression in the second and third trimesters among women who
    drank in the first trimester.
  • Prenatal and Postnatal Maternal Stress and Wheeze in Urban Children: Effect of Maternal Sensitization Yueh-Hsiu Mathilda Chiu, 2012, PMCID: PMC3406080
  • Sengupta P., 2012, Health Impacts of Yoga and Pranayama: A State-of-the-Art Review, PMID: 22891145
  • Heart coherence: Personal stress relief, Social fulfillment, Global Hope and optimism - Heart-Brain Neurodynamics: The Making of Emotions Rollin McCraty, Ph.D. - In Issues of the Heart: The Neuropsychotherapist special issue, M. Dahlitz, & Hall, G., Editor 2015, Dahlitz Media: Brisbane. p. 76-110.
  • Cardiac Coherence, Self-Regulation, Autonomic Stability, and Psychosocial Well-Being Rollin McCraty Ph.D.1 and Maria A Zayas Ph.D.2
  • Frontiers in Psychology, Sept. 2014. Vol. 5, Article 1090.The Effects of Different Types of Music on Mood, Tension, and Mental Clarity PR R. McCraty, B. Barrios-Choplin,